Choroid plexus volume linked to Alzheimer’s disease 

 April 8, 2022

MRI control procedures. For volumetry (left), volume choroid plexus (CP) (red) and cerebral cortex volume (green) were separated from T1-weighted images using automatic volumetric software (Inbrain) based on the FreeSurfer 6.0 platform ( list above). High-resolution (WMH) volumes (green) are also separated from three-dimensional (3D) or two-dimensional (2D) water-attenuated inversion-recovery (FLAIR) software using different software one (list below). The number of shared masks are binary. To receive a simple map (right), permanent value (constant transfer volume [Ktrans] and plasma volume) are obtained from MRI scanners using the Patlak method, and the CP values ​​are extracted using the CP (red) correlation of T1-weighted images to the point-and-shoot map use each other’s data. – root algorithm (top row). The color scale represents a constant change of volume (within min21). Infection measures are provided by comparison. QSM mapping is obtained from multiecho multidynamic images using QSMnet1 (bottom line). Gray carcass represents a defect in parts over a million. Credit: North American Radio Association

Increased volume of an important structure in the brain called the choroid plexus is associated with dementia and Alzheimer’s disease, according to a new study published in the journal. Radiology.

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The choroid plexus is a network of blood vessels, connective tissue and cells found in the space of the brain called the ventricles. The plexus plays an important role in brain health. It is a door to antibiotics from blood to brain. As the primary source for cerebrospinal fluid supply, it is important to clear waste products and toxic chemicals from Brain cells. This role is especially important in the case of Alzheimer’s disease. Recent research suggests that disease progression it is associated with the accumulation of small amounts of proteins called amyloid and tau and subsequent nerve degeneration.

“Researchers believe that it is less effective than amyloid depletion and that it is responsible for Alzheimer’s disease,” said Won-Jin Moon, MD, Ph.D., professor of radiology and head of the Department of Radiology at University of Konkuk. School of Medicine in Seoul, Korea. “Therefore, we hypothesized that the abnormal condition of the choroid plexus is related to the failure of clearing of waste products and the accumulation of toxic proteins in the brain and the failure of immune control to cause neuroinflammation.”

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Little is known about the photo data of the choroid plexus in the misunderstanding.

To learn more, Dr. Moon and colleagues performed MRI of the brain on 532 participants at different stages of comprehension. Of the 532 participants, 132 underwent imaging modalities using a computed tomography MRI.

Myocardial infarction (CRI) myocardial infarction MRI. Cholesterol triglyceride levels are higher in those with Alzheimer’s dementia than in those without them. Chorinoid size depends on the size of the memory. It also has a detrimental effect on executive function, a huge benefit of mindfulness that drives things like self-control and planning.

Choroid plexus growth is associated with Alzheimer's disease

Comparison of four agents of 3.0-T brain MRI of ultrasound of the choroid plexus (CP) growth (red) according to the degree of disease on the basis of incompatibility. The incidence of CP is higher in patients with Alzheimer’s disease (AD) than those with cognitive impairment (SCI) or mild cognitive impairment (MCI). All patients are women aged 75. Credit: North American Radio Association

“Our research has found that the size of the choroid plexus is directly related to the degree of cognitive impairment,” Dr. Moon said. “We did not find a correlation between the volume of the choroid plexus and amyloid pathology but a positive correlation between the volume of the choroid plexus and misunderstanding seriously. “

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The results of the study suggest new opportunities to use MRI in the diagnosis of Alzheimer’s disease.

“I think our recent findings on the choroid plexus may suggest it as a new potential MR imaging surrogate for systemic disease and neuroinflammation,” Dr. Moon said.

Other potential clinical applications include helping researchers develop new therapies or treatments for failure to clear neuroinflammation. Finally, the balance of the choroid plexus can help speed up treatment for those who need it most.

“If we combine the volume of the choroid plexus and the volume of the hippocampal in the display stages, it can help us better to differentiate patients from patients,” said Dr. Moon.

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The researchers planned to follow up on long study. They will investigate changes in it choroid plexus grow over time as the disease progresses.

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Learn more:
Jong Duck Choi et al, Choroid Plexus Volume and Permeability in Brain MRI in Alzheimer’s Disease, Radiology (2022). DOI: 10.1148 / radiol.212400

Its formation
North American Radio Association

hint: Choroid plexus growth associated with Alzheimer’s disease (2022, May 17) Retrieved 17 May 2022 from https://medicalxpress.com/news/2022-05-choroid-plexus-volume-linked-alzheimer.html

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