Increased volume of an important structure in the brain called the choroid plexus is associated with dementia and Alzheimer’s disease, according to a new study published in the journal. Radiology.
The choroid plexus is a network of blood vessels, connective tissue and cells found in the space of the brain called the ventricles. The plexus plays an important role in brain health. It is a door to antibiotics from blood to brain. As the primary source for cerebrospinal fluid supply, it is important to clear waste products and toxic chemicals from Brain cells. This role is especially important in the case of Alzheimer’s disease. Recent research suggests that disease progression it is associated with the accumulation of small amounts of proteins called amyloid and tau and subsequent nerve degeneration.
“Researchers believe that it is less effective than amyloid depletion and that it is responsible for Alzheimer’s disease,” said Won-Jin Moon, MD, Ph.D., professor of radiology and head of the Department of Radiology at University of Konkuk. School of Medicine in Seoul, Korea. “Therefore, we hypothesized that the abnormal condition of the choroid plexus is related to the failure of clearing of waste products and the accumulation of toxic proteins in the brain and the failure of immune control to cause neuroinflammation.”
Little is known about the photo data of the choroid plexus in the misunderstanding.
To learn more, Dr. Moon and colleagues performed MRI of the brain on 532 participants at different stages of comprehension. Of the 532 participants, 132 underwent imaging modalities using a computed tomography MRI.
Myocardial infarction (CRI) myocardial infarction MRI. Cholesterol triglyceride levels are higher in those with Alzheimer’s dementia than in those without them. Chorinoid size depends on the size of the memory. It also has a detrimental effect on executive function, a huge benefit of mindfulness that drives things like self-control and planning.
“Our research has found that the size of the choroid plexus is directly related to the degree of cognitive impairment,” Dr. Moon said. “We did not find a correlation between the volume of the choroid plexus and amyloid pathology but a positive correlation between the volume of the choroid plexus and misunderstanding seriously. “
The results of the study suggest new opportunities to use MRI in the diagnosis of Alzheimer’s disease.
“I think our recent findings on the choroid plexus may suggest it as a new potential MR imaging surrogate for systemic disease and neuroinflammation,” Dr. Moon said.
Other potential clinical applications include helping researchers develop new therapies or treatments for failure to clear neuroinflammation. Finally, the balance of the choroid plexus can help speed up treatment for those who need it most.
“If we combine the volume of the choroid plexus and the volume of the hippocampal in the display stages, it can help us better to differentiate patients from patients,” said Dr. Moon.
The researchers planned to follow up on long study. They will investigate changes in it choroid plexus grow over time as the disease progresses.
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Jong Duck Choi et al, Choroid Plexus Volume and Permeability in Brain MRI in Alzheimer’s Disease, Radiology (2022). DOI: 10.1148 / radiol.212400
North American Radio Association
hint: Choroid plexus growth associated with Alzheimer’s disease (2022, May 17) Retrieved 17 May 2022 from https://medicalxpress.com/news/2022-05-choroid-plexus-volume-linked-alzheimer.html
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